Cell Type Influences Local Delivery of Biomolecules from a Bioinspired Apatite Drug Delivery System

vancomycin loaded chitosan beads as a drug delivery system for local antibiotic delivery in some infections

Phytosome: Drug Delivery System for Polyphenolic Phytoconstituents

      Several plant extracts and phytoconstituents, despite having excellent bioactivity in vitro, demonstrate less or no in vivo actions due to their poor lipid solubility or improper molecular size or destruction in gut. Drug delivery system for polyphenolic phytoconstituents (phytosomes) was prepared by complexing polyphenolic phytoconstituents with phospholipid mainly phosphatidylcholine wh...

Local Drug Delivery

Periodontal diseases are considered infection of the periodontium, because there is bacterial etiology, an immune response, and tissue destruction. Putative pathogens associated with periodontal diseases are susceptible to a variety of antiseptics and antibiotics. Methods employed to convey antimicrobial agents into periodontal pockets have included rinsing, irrigation, systemic administration,...

Role of Nanodiamonds in Drug Delivery and Stem Cell Therapy

Context: The use of nanotechnology in medicine and more specifically drug delivery is set to spread rapidly. Currently many substances are under investigation for drug delivery and more specifically for cancer therapy. Evidence Acquisition: Nanodiamonds (NDs) have contributed significantly in the development of highly efficient and successful drug delivery systems, and in stem cell therapy. Dru...

Biocompatability of hydroxyapatite composite as a local drug delivery system.

PURPOSE To investigate the biocompatibility of hydroxyapatite composite (hydroxyapatite, plaster of Paris, and chitosan) impregnated with gentamicin, fosfomycin, imipenem, or amphotericin B. METHODS The interactions of the extract from each drug against osteoblast were tested using the methylthiotetrazole test. RESULTS Extracts from all drugs showed good biocompatibility at concentrations v...